Microbial control of intestinal innate immunity

Microbial control of intestinal innate immunity

Intestinal innate immunity, a critical component of the intestinal barrier to noxious agents, is a master regulator of intestinal health. Dysregulation of intestinal innate immune features are pathognomonic of disease states such as inflammation and cancer [1]. The implication of loss of intestinal barrier function to human health is broad and goes beyond oncogenesis [2, 3]. Thus, a complete un...

Remote control of intestinal tumorigenesis by innate immunity.

Chronic intestinal inflammation has been linked to the development of colorectal cancer. Recent studies suggest that during chronic inflammation, the innate immune system may facilitate colon tumorigenesis in genetically predisposed individuals in response to certain indigenous microorganisms and/or cell remnants. In these individuals, therapeutic approaches that reroute the innate immune syste...

Human Intestinal Epithelial Cells in Innate Immunity

NFAT control of innate immunity.

The calcineurin/nuclear factor of activated T cells (NFAT) signaling pathway mediates multiple adaptive T-cell functions, but recent studies have shown that calcineurin/NFAT signaling also contributes to innate immunity and regulates the homeostasis of innate cells. Myeloid cells, including granulocytes and dendritic cells, can promote inflammation, regulate adaptive immunity, and are essential...

Microbial Programming of Systemic Innate Immunity and Resistance to Infection

A multicellular organism is subject to constant microbial exposure throughout its life. These interactions can be transient or permanent, with microbes ranging from those considered commensal to pathogenic [1]. The initial host response to these myriad microbes relies upon the innate immune system. This highly conserved and ancient arm of host defense has generally been thought of as hardwired ...